Fluoromethyl phenyl sulfone Basic information |
Product Name: | Fluoromethyl phenyl sulfone |
Synonyms: | Fluoromethanesulfonyl-benzene;FLUOROMETHYL PHENYL SULFONE;FLUOROMETHYLSULFONYLBENZENE;Phenyl Fluoromethyl Sulfone;FluoromethylPhenylSulfone>;Benzene, [(fluoromethyl)sulfonyl]- |
CAS: | 20808-12-2 |
MF: | C7H7FO2S |
MW: | 174.19 |
EINECS: | |
Product Categories: | Biochemistry;Fluorinated Building Blocks;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;Reagents for Oligosaccharide Synthesis;Sulfur Compounds (for Synthesis);Synthetic Organic Chemistry |
Mol File: | 20808-12-2.mol |
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Fluoromethyl phenyl sulfone Chemical Properties |
Melting point | 53 °C |
Boiling point | 151 °C(Press: 0.3 Torr) |
density | 1.274±0.06 g/cm3(Predicted) |
Safety Information |
Safety Statements | 24/25 |
HS Code | 29309090 |
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MSDS Information |
SULPHO [...] (1, 2-A) PYRAZINE COMPOUNDS AS BLOCKED RES OF CALCIUM CHANNELSCurrent Patent Assignee: ABBVIE INC - AR088064, 2014, A1
Patent Family Members: AR088064 A1; TW2013/21384 A; US2013/85141 A1; US8648074 B2; UY34349 A; ...
Abstract
The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein Z', Z'', L2, G2, R1, and R2 are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use as calcium channel blockers.
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Facile synthesis of α-monofluoromethyl alcohols: Nucleophilic monofluoromethylation of aldehydes using TMSCF(SO2Ph)2[Journal of Fluorine Chemistry, 2012, vol. 133, p. 27 - 32]
Abstract
α-Fluoromethyl phenyl sulfone derivatives have been extensively employed in various reactions as versatile fluoromethylating reagents. While nucleophilic monofluoromethylations of aldehydes have been achieved using fluoromethyl phenyl sulfone or fluorobis(sulfonyl)methanes, a facile protocol under mild reaction conditions remains an ardently sought goal. We now report a feasible synthetic approach toward β-monofluorinated alcohols using α-trimethylsilyl-α-fluorobis(phenylsulfonyl)methane [TMSCF(SO 2Ph)2, TFBSM] as a novel monofluoromethylating reagent. Initiated by a catalytic amount of fluoride, the reagent can be readily added to a variety of aldehydes providing the desired products in high yields. Computational and kinetic studies have revealed the exceptional lability of the Si-C bond in TFBSM compared with other fluoromethylsilane counterparts.
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Stereoselective nucleophilic monofluoromethylation of N-(tert- butanesulfinyl)imines with fluoromethyl phenyl sulfone[Organic Letters, 2006, vol. 8, # 8, p. 1693 - 1696]
Abstract
Highly stereoselective nucleophilic monofluoromethylation of (R)-(tert-butanesulfinyl)imines with fluoromethyl phenyl sulfone was achieved to afford α-monofluoromethylamines with a nonchelation-controlled stereoselectivity mode. By using the same chemistry, (R)-(tert-butanesulfinyl)- imines bearing a terminal tosylate (OTs) group can be converted to α-monofluoromethylated cyclic secondary amines with high stereoselectivity.
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