CAS:114435-86-8，fluoromethyl p-tolyl sulfone

Disclosed is a molecular imaging method for evaluating liver regeneration ability after ALPPS. The method includes steps of: 1) preparing a VX2 rabbit liver cancer model; 2) performing ALPPS for the VX2 rabbit liver cancer model; 3) synthesizing 18F-Fluoromethylcholine (18F-Methylcholine, 18F-FCH); 4) PET/CT imaging and data processing for 18F-FCH. The disclosure is the first to propose the use of 18F-FCH PET/CT to monitor the proliferative capacity of residual liver, and further indirectly reflect the increased ability of cell membrane synthesis on the basis that 18F-FCH has higher choline metabolism in residual liver tissue, so that the liver regeneration ability after ALPPS is evaluated by the molecular imaging method, thereby providing important new ideas for the clinical selection of ALPPS to choose the best time for second-stage surgery.

The invention relates to the field of chemical synthesis, in particular to a high-purity fluoromethyl p-toluenesulfonate production process, which comprises fluoromethyl p-toluenesulfonate productionand toluenesulfonate production. The fluoromethyl p-toluenesulfonate production comprises the following steps of S1, melting: putting p-toluenesulfonate into a melting tank with stirring and heating functions, meanwhile, adding a specified amount of water, starting a motor on the melting tank to stir p-toluenesulfonate, and meanwhile, starting the heating function of the p-toluenesulfonate, and S2, pressurizing and fusing: pouring the molten p-toluenesulfonate liquid into a pressurizing tank, and adding a catalyst copper trifluoromethanesulfonate into the pressurizing tank. The production process has the beneficial effects that the molar ratio of fluoroX methane to p-toluenesulfonate is 1: 1, a nucleophilic substitution principle is adopted, and one-step reaction is carried out, so that the synthesis process is simplified, the production efficiency of fluoromethyl p-toluenesulfonate is high, and the purity of the obtained fluoromethyl p-toluenesulfonate is high.

The present invention relates to a method for preparing a fluorine-18-labeled fluoromethyl-substituted radiopharmaceutical using selective azide substitution reaction, the method comprising: a first step for obtaining [<18>F]fluoride from a cyclotron through a <18>O(p, n)<18>F reaction; a second step for obtaining a [<18>F]F-/H2 18O solution by separating the [<18>F]fluoride using an acetonitrile reaction solution in which K2.2.2 and K2CO3 are dissolved; a third step for obtaining K2.2.2/K<18>F by heating the [<18>F]F-/H2<18>O solution; a fourth step for obtaining a first precursor solution by adding the K2.2.2/K<18>F and a bis(toxyloxy)methane compound into a reactor and adding a reaction solvent thereto to cause reaction; a fifth step for obtaining a [<18>F]fluoromethyltosylate compound by cooling the first precursor solution and adding an azide reagent thereto to cause azide substitution reaction.