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Fluorine intermediates

  • CAS:373-53-5,Fluoroiodomethane
CAS:373-53-5,Fluoroiodomethane

CAS:373-53-5,Fluoroiodomethane

  • Specification:99.8%
  • Properties:Liquid
  • Package:fluorinated bottle
  • Usage:Pharmaceutical intermediates
  • Product description: CAS:373-53-5 | Product Name: fluoroiodomethane 99.8%, colorles or micro red transparent liquid, medium boiling point 53 ℃, is a good substitute for bromofluoromethane, with higher activity, lower vapo
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fluoro-iodo-methane Basic information

room temperature use, environment-friendly and other special effects is an important raw material for fluticasone, fluticasone propionate, fluticasone fluticasone furoate.

Product Name: fluoro-iodo-methane
Synonyms: fluoro-iodo-methane;Fluoromethyl iodide;Fluoroiodomethane 95%;Methane, fluoroiodo- (6CI,8CI,9CI);Fluoroiodomethane (ca. 2mol/L in Acetonitrile)
CAS: 373-53-5
MF: CH2FI
MW: 159.93
EINECS:
Product Categories:
Mol File: 373-53-5.mol

https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsc.202200493


fluoro-iodo-methane Chemical Properties
Boiling point 53.4℃
density 2.366 g/cm3 (20 ºC)
refractive index 1.491 (589.3 nm 20℃)
CAS DataBase Reference 373-53-5
Safety Information

MSDS Information
fluoro-iodo-methane Usage And Synthesis
Uses Fluoroiodomethane is an synthetic precursor for the fluoromethylation of radiopharmaceuticals.


fluoro-iodo-methane Preparation Products And Raw materials





Nickel-catalyzed hydromonofluoromethylation of unactivated alkenes for expedient construction of primary alkyl fluorides

Ni, Shan-Xiu; Li, Yan-Lin; Ni, Hui-Qi; Bi, Yu-Xiang; Sheng, Jie; Wang, Xi-Sheng [Chinese Chemical Letters, 2023, vol. 34, # 3, art. no. 107614]


Abstract

A nickel-catalyzed direct hydromonofluoromethylation of unactivated olefins with industrial raw Fluoroiodomethane is developed, furnishing various primary alkyl fluorides in a step-economic manner. The key factor to success is the use of pyridine-oxazoline as ligand and (MeO)2MeSiH as the hydrogen source. This transformation demonstrates high efficiency, mild conditions, good functional-group compatibility and great potential in the drug discovery.

Photoredox-Catalyzed and Silane-Mediated Hydrofluoromethylation of Unactivated Alkenes with Fluoroiodomethane in Water

Hu, Chen-Chen; Tong, Chao-Lai; Zhang, Yu-Yang; Xu, Xiu-Hua; Qing, Feng-Ling [Organic Letters, 2023, vol. 25, # 6, p. 1035 - 1039]


Abstract

The first hydrofluoromethylation of unactivated alkenes with Fluoroiodomethane and hydrosilanes is developed by merging photoredox catalysis and silane-mediated deiodination processes. The key to the success of this reaction is the use of water as the solvent to enhance the activity of CH2F radical toward unactivated alkenes.

An end-capping method for perfluoropolyethers

Current Patent Assignee: ZHEJIANG JUHUA TECH CENTER CO LTD - CN114573803, 2023, B
Patent Family Members: CN114573803 A; CN114573803 B


Abstract

The invention discloses an end-capping method of perfluoropolyether, which comprises the following steps: carrying out end-capping reaction on raw materials of perfluoropolyether acyl fluoride, a fluorinating agent, a catalyst and an end-capping agent in a solvent to obtain inert polyether of which the end group contains hydrogen atoms. The method solves the problems of low reaction efficiency, high risk, harsh process conditions and the like of the existing end capping method, and has the advantages of mild reaction conditions, high efficiency, economy, safety and environmental protection.