2-Fluoroethyl 4-methylbenzenesulfonate Basic information |
Product Name: | 2-Fluoroethyl 4-methylbenzenesulfonate |
Synonyms: | Fluoroethylp-tosylate;2-Fluoro-(4-methylbenzenesulfonate)ethanol;FLUOROETHYL 4-TOLUENESULFONATE;2-FLUOROETHYL TOSYLATE;L-TRYPTOPHAN/D-TRYPTOPHAN;2-fluoroethyl 4-methylbenzenesulfonate;Fluoroethyl p-toluenesulfonate;4-Methylbenzenesulfonic acid 2-fluoro-ethyl ester |
CAS: | 383-50-6 |
MF: | C9H11FO3S |
MW: | 218.25 |
EINECS: | |
Product Categories: | |
Mol File: | 383-50-6.mol |
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2-Fluoroethyl 4-methylbenzenesulfonate Chemical Properties |
Boiling point | 140°C/1mmHg(lit.) |
density | 1.290 g/cm3 |
refractive index | 1.5060 to 1.5100 |
CAS DataBase Reference | 383-50-6(CAS DataBase Reference) |
Safety Information |
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MSDS Information |
2-Fluoroethyl 4-methylbenzenesulfonate Usage And Synthesis |
2-Fluoroethyl 4-methylbenzenesulfonate Preparation Products And Raw materials |
Raw materials |
AN IMPROVED SYNTHESIS OF [18F] - FLUOROALKYL TOSYLATECurrent Patent Assignee: GE HEALTHCARE TECHNOLOGIES INC - KR102234143, 2021, B1
Patent Family Members: CN105452203 A; CN105452203 B; EP3036209 A1; EP3036209 B1; ES2687196 T3; ...
Abstract
[18F]-fluoralkyl tosylates are useful building block for the radiosynthesis of a number of small molecules. A method of purifying [18F]-fluoroalkyl tosylates using an automated radiosynthesis apparatus (e.g. FASTlab module) is described. A method of purifying [18F]-fluoroalky tosylates using a FASTlab module that includes a solid phase extraction (SPE) purification system is described.
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Tetrabutylammonium tosylate as inert phase-transfer catalyst: The key to high efficiency SN2 radiofluorinations[Applied Radiation and Isotopes, 2020, vol. 163, art. no. 109195]
Abstract
Here we describe use of the tetrabutylammonium p-toluenesulfonate (TBAOTs) as an inert phase transfer catalyst allowing high efficient aliphatic radiofluorination of labeling precursors for the preparation of common radiotracers using only 0.2–1.2 mg of the substrates. With operational convenience (no need for azeotropic drying) and compatibility with the common types of strong anion-exchange cartridges (QMA), this method has a high potential for routine application in various automated synthesizers and offers significant costs reductions due to less precursors used.
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AN IMPROVED SYNTHESIS OF [18F]- FLUOROALKYL TOSYLATECurrent Patent Assignee: GE HEALTHCARE TECHNOLOGIES INC - EP3036209, 2018, B1
Patent Family Members: CN105452203 A; CN105452203 B; EP3036209 A1; EP3036209 B1; ES2687196 T3; ...
Abstract
[18F]-fluoralkyl tosylates are useful building block for the radiosynthesis of a number of small molecules. A method of purifying [18F]-fluoroalkyl tosylates using an automated radiosynthesis apparatus (e.g. FASTlab module) is described. A method of purifying [18F]-fluoroalky tosylates using a FASTlab module that includes a solid phase extraction (SPE) purification system is described.
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