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Difluoromethyl 2-pyridyl sulfone Basic information
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Product Name:
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Difluoromethyl 2-pyridyl sulfone
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Synonyms:
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Pyridine, 2-[(difluoroMethyl)sulfonyl]-;2-[(DifluoroMethyl)sulfonyl]pyridine;DifluoroMethyl 2-Pyridyl Sulfone;Difluoromethyl 2-pyridyl sulfone 97% (HPLC);2-(Difluoromethanesulfonyl)pyridine;2-PySO2CF2H;Hu Reagent;2-[(DifL
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CAS:
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1219454-89-3
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MF:
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C6H5F2NO2S
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MW:
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193.17
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EINECS:
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Product Categories:
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Aromatics;Heterocycles;Sulfur & Selenium Compounds
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Mol File:
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1219454-89-3.mol
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Difluoromethyl 2-pyridyl sulfone Chemical Properties
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Melting point
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47.0 to 51.0 °C
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Boiling point
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324.4±42.0 °C(Predicted)
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density
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1.423±0.06 g/cm3(Predicted)
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pka
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-2.60±0.19(Predicted)
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BRN
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20317604
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Hazard Codes
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T
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Risk Statements
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25-36
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Safety Statements
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26-45-24/25
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RIDADR
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UN 2811 6.1 / PGIII
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WGK Germany
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3
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HS Code
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29339900
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Difluoromethyl 2-pyridyl sulfone Usage And Synthesis
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Uses
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2-[(Difluoromethyl)sulfonyl]pyridine is a new novel gem-difluoroolefination reagent for both aldehydes and ketones.
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Difluoromethyl 2-pyridyl sulfone Preparation Products And Raw materials
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Benzoyl fluoride compound, benzoic acid compound and preparation method thereof
Current Patent Assignee: CHONGQING MEDICAL UNIVERSITY - CN115710200, 2023, A
Patent Family Members: CN115710200 A
Abstract
The invention relates to a benzoyl fluoride compound, a benzoic acid compound and a preparation method thereof, and relates to the technical field of chemical synthesis, the preparation method of the benzoyl fluoride compound comprises the following steps: S1, in a protective atmosphere, mixing a cyclohexadienone compound with difluoromethyl 2-pyridyl sulfone to form a mixture, then adding N, N-dimethyl formamide of sodium alkoxide or potassium alkoxide, and carrying out a reaction for 2-4 hours to obtain a benzoyl fluoride compound; adding N, N-dimethylformamide and mixing; s2, acidifying the mixed solution obtained in the step S1; the preparation method of the benzoic acid compound comprises the following steps: S1, under a protective atmosphere, mixing a cyclohexadienone compound with difluoromethyl 2-pyridyl sulfone to form a mixture, adding N, N-dimethylformamide of sodium alcoholate or potassium alcoholate, and mixing; and S2, adding concentrated hydrochloric acid into the mixed solution obtained in the step S1. The invention provides a novel nonmetal catalysis method for benzene ring acylation, and benzoyl fluoride and benzoic acid compounds can be prepared.
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Preparation of benzoyl fluorides and benzoic acids from phenols via a dearomatization-rearomatization strategy
Yang, Meixian; Huang, Xinyue; Miao, Wenjun; Yi, Lan; Cai, Jiajing; Zhao, Zhenghuan; He, Jia; Qiu, Dachuan [Organic Chemistry Frontiers, 2023, vol. 10, # 8, p. 1975 - 1980]
Abstract
We describe here a method to generate both benzoyl fluorides and benzoic acids using 2,5-cyclohexadienones prepared from phenols via oxidative dearomatization. 2,5-Cyclohexadienones react with difluoromethyl 2-pyridyl sulfone under basic conditions to give gem-difluoroolefins in situ, which could be attacked by nucleophiles and further aromatized to form benzoyl fluorides. By changing the reaction conditions, benzoic acids could be formed efficiently in a one-pot fashion as well. The mild conditions and broad substrate scope make this transformation a unique approach for formal deoxyacylation of phenols without transition metal catalysis.
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Preparation method of difluoromethyl (2-pyridyl) sulfone compound
Current Patent Assignee: ZHEJIANG JIUZHOU PHARM CO LTD - CN116730911, 2023, A
Patent Family Members: CN116730911 A
Abstract
The invention belongs to the field of organic synthesis, and particularly relates to a preparation method of difluoromethyl (2-pyridyl) sulfone. Difluoromethyl (2-pyridyl) sulfone is prepared from a compound 2-(difluoromethylmercapto) pyridine shown in a formula I through an oxidation reaction, and in the oxidation reaction, an oxidation reagent is a bromate compound or a mixture of the bromate compound and water. # imgabs0 #
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