Fluorine intermediates

CAS:2143892-50-4，SulfoxFluor，4-Chloro-N-tosylbenzenesulfonimidoyl fluoride

Specification：99%
Properties：White solid
Package：Glass bottle, fluorinated bottle
Usage：Pharmaceutical intermediates
Product description: CAS:2143892-50-4 | SulfoxFluor ，4-Chloro-N-tosylbenzenesulfonimidoyl fluoride，Molecular formula :C13H11ClFNO3S2 Molecular weight :347.81 Boiling point 488.8±55.0 °C(Predicted) Density 1.42±0.1 g/cm3(P
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4-chloro-N -[(4-methylphenyl) sulfonyl] -phenyl sulfonamide fluoride Basic information

Chinese name: 4 - chloro - N - [(4 - methyl phenyl) sulfonyl] - benzene sulfonamide acyl fluoride Chinese synonyms 4 - chloro - N - [(4 - methyl phenyl) sulfonyl] - benzene sulfonamide acyl fluoride; 4-chloro-N -[(4-methylphenyl) sulfonyl] benzene sulfonimide fluoride; 4-chloro-N -[(4-methylphenyl) sulfonyl] phenyl sulfonamide fluoride; 4 - chloro - N - [(4 - methyl phenyl) sulfonyl] benzene sulfonamide acyl fluoride, chlorine - 4 - N - [(4 - methyl phenyl) sulfonyl] benzene sulfonamide acyl fluoride, chlorine - 4 - N - [(4 - methyl phenyl) sulfonyl] benzene sulfonyl imide fluorine. Fluorinated reagent

English name: 4 - Chloro - N - 4 - Chloro - N - tosylbenzenesulfonimidoylfluoride tosylbenzenesulfonimidoylfluoride English synonyms; 4-Chloro-N-[(4-methylphenyl)sulfChemicalbookonyl]-benzenesulfonimidoylfluoride; Benzenesulfonimidoylfluoride,4-chloro-N-[(4-methylphenyl)sulfonyl]-; SulfoxFluor; Sulfoxfluro; Sulfoxfluro,4-Chloro-N-[(4-methylphenyl)sulfonyl]-benzenesulfonimidoylfluoride,4-Chloro-N-tosylbenzenesulfonimidoylfluor ide

CAS number 2143892-50-4

Molecular formula C13H11ClFNO3S2

Molecular weight 347.81EINECS number

Related categories Mol File 2143892-50-4.mol

Boiling point 488.8±55.0°C(Predicted)

Density 1.42±0.1g/cm3(Predicted)

PROCESSES OF MAKING 3-FLUORO-5-(((1R,2S,2AS)-1,2,3,3,4,4-HEXAFLUORO-2A-HYDROXY-2,2A,3,4-TETRAHYDRO-1H- CYCLOPENTA[CD]INDEN-7-YL)-OXY)-BENZONITRILE AND POLYMORPHS THEREOF

Current Patent Assignee: NIKANG THERAPEUTICS INC - WO2023/76532, 2023, A1

Patent Family Members: WO2023/70483 A1; WO2023/76532 A1

Abstract

The present disclosure provides certain processes of making 3-fluoro-5-(((1R,2S,2aS)- 1,2, 3,3,4, 4-hexafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)oxy)- benzonitrile and certain polymorphs thereof. Also provided are pharmaceutical compositions comprising a crystalline polymorph form of Compound (I) and processes for preparing such polymorph forms.

PROCESSES OF MAKING 3-FLUORO-5- ( ( (1R, 2S, 2aS) -1, 2, 3, 3, 4, 4-HEXAFLUORO-2A-HYDROXY-2, 2A, 3, 4-TETRAHYDRO-1H-CYCLOPENTA [CD] INDEN-7-YL) -OXY) -BENZONITRILE AND POLYMORPHS THEREOF

Current Patent Assignee: NIKANG THERAPEUTICS INC - WO2023/70483, 2023, A1

Patent Family Members: WO2023/70483 A1; WO2023/76532 A1

Abstract

The present disclosure provides certain processes of making 3-fluoro-5- (((1R, 2S, 2aS) -1, 2, 3, 3, 4, 4-hexafluoro-2a-hydroxy-2, 2a, 3, 4-tetrahydro-1H-cyclopenta [cd] inden-7-yl) oxy) -benzonitrile and certain polymorphs thereof. Also provided are pharmaceutical compositions comprising a crystalline polymorph form of Compound (I) and processes for preparing such polymorph forms.

3-fluoro-5-((1S,2aR)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)oxy)-benzonitrile preparation method

Current Patent Assignee: NIKANG THERAPEUTICS INC - KR2023/92936, 2023, A

Patent Family Members: AU2021364337 A1; CA3197932 A1; IL301897 A; KR2023/92936 A; TW2022/33569 A; ...

Abstract

Disclosed herein are processes for preparing 3-fluoro-5-(((1S,2aR)-1,3,3,4,4- pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)oxy)benzonitrile (hereinafter as compound (I) having the following structure).

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